New applications for these assignments are welcome from begin-2026. I have no space for new students in 2025.
It is essential to detect cancer as early as possible for a good prognosis. Some lesions are only visible on MRI and not with ultrasound, mammography (x-ray) or CT. A biopsy is needed to take a tissue sample for examination. A confirmed malignant tumour subsequently needs to be treated, and some approaches also use a needle to remove or destroy the tumour (e.g., electroporation, cryoablation or medicine injection). However, it isn't easy to insert a needle manually into the right location. Could a robot do better?
Due to the strong magnetic field of an MRI scanner, we cannot use electromagnetic motors to actuate robots in the MRI. At RaM, we use 3-D printed pneumatic stepper motors instead. Sunram is a series of robots for breast biopsy which has been under development since 2014 (video). Mamri is a generic instrument positioning robot arm with six degrees of freedom and a relatively large workspace, for which development started in 2024 (video).
The Sunram and Mamri robots actually turn out to be quite fun to work and play with. Several MSc/BSc assignments are possible within the context of Sunram and Mamri robot arms. So far, around twenty students have conducted such a project. Keywords are:
- Robot control (steer the needle towards the tumour)
- Automatic calibration (fibre optics?)
- Motion compensation (breathing and needle-tissue interaction; compensate using real-time MRI imaging via Access-I interface or other means)
- Human-machine interfacing (develop an intuitive user interface, 6 DOF joystick? also for demos), see video
- Develop new stepper motors (focus on mechanical engineering), see video
- Develop a new robot using existing stepper motors (prostate biopsy robot? Sunram 8?)
- Write out a full clinical workflow (which organs are most relevant? which system parts are disposable, sterilizable?) for Health Science students
- End-effector design (does it align the needle guide only, or also insert the needle itself and fire the biopsy gun?)
- Force sensing (based on fibre optics or pneumatics?)
- Digital twin (virtual/mixed reality, using HoloLens 2 or other device), see video
- Phantom fabrication (sometimes part of a broader assignment)
Depending on your background (study programme and courses) and personal interests, we can see if we can draft a specific assignment around any of these topics.
Contact me at v.groenhuis@utwente.nl, and I will gladly show you what keeps us busy in the lab.