Background:
Quantitative myocardial perfusion imaging can improve the diagnosis and evaluation of coronary artery disease, but needs to be reliably validated across imaging modalities. Physical perfusion phantoms provide an environment in which image-derived flow values can be compared to known flow settings. Current myocardial perfusion phantoms are often static or only compatible with one modality.
Methodology:
The focus is to rebuild the Twente Myocardial Perfusion phantom and improve logistics in the flow circuit. The phantom is a 3D-printed myocardial flow phantom that mimics a left ventricular cavity and 3 surrounding myocardial regions. The closed flow circuit provides reusability and constant adjustability with multiple adjustable resistances to mimic healthy flow or a perfusion deficit with constant flow measurements throughout the circuit with custom made software. This will be compared to values obtained under multiple imaging modalities.
Research question:
Can the TMP phantom simulate realistic, reproducible myocardial flow in multiple imaging modalities?
